This book will take us through the journey of safety in our hospital, household, and community. Also, key tips and friendly acronyms will be used to unlock the safety in our hospitals and immediate environments. All these are targeted at relieving the stress and consequences of poor safety culture. This book is not the typical everyday safety/ infection control manual. It is a holistic book that explored control of infection and adherence to good safety culture in unusual or unconventional ways without overwhelming the readers with unnecessary medical jargon/physiology. In addition, this book is very useful considering the ravaging effects and catastrophic consequences of the Covid-19 pandemic. Furthermore, this book gave a clear step to step mode of safety precaution from our homes to the community and hospital. Also in this book are published articles of the author, these articles are met to give a clear view of health care exposure to blood and body fluids, adherence to standard precautions, and Nigerian experience of Covid-19(paradigm shift and issues arising).